October 15, 2021 11:44 AM
| # | Team | Player | POS | College |
|---|---|---|---|---|
| Jacksonville | Evan Neal | OT | Alabama | |
| Detroit | Matt Corral | QB | Mississippi | |
| Philadelphia (from Miami) | Malik Willis | QB | Liberty | |
| Houston | Kayvon Thibodeaux | DE | Oregon | |
| NY Jets | Kyle Hamilton | S | Notre Dame | |
| Philadelphia (from Indianapolis) | Derek Stingley | CB | LSU | |
| NY Giants | Aidan Hutchinson | DE | Michigan | |
| New England | DeMarvin Leal | DT | Texas A&M | |
| Atlanta | Carson Strong | QB | Nevada | |
| NY Jets (from Seattle) | Drake London | WR | Southern California | |
| Miami (from San Francisco) | Drake Jackson | LB | Southern California | |
| Philadelphia | Kenyon Green | G/T | Texas A&M | |
| Washington | Charles Cross | OT | Mississippi State | |
| Minnesota | Jordan Davis | DT | Georgia | |
| Pittsburgh | Adam Anderson | OLB | Georgia | |
| Kansas City | Kaiir Elam | CB | Florida | |
| New Orleans | Jahan Dotson | WR | Penn State | |
| Cleveland | Garrett Wilson | WR | Ohio State | |
| Tennessee | Ikem Ekwonu | G/T | North Carolina State | |
| Denver | Sam Howell | QB | North Carolina | |
| Cincinnati | Jaxson Kirkland | OT | Washington | |
| Carolina | Trevor Penning | OT | Northern Iowa | |
| Las Vegas | Andrew Booth | CB | Clemson | |
| NY Giants (from Chicago) | Devin Lloyd | LB | Utah | |
| Buffalo | Roger McCreary | CB | Auburn | |
| Tampa Bay | Ahmad Gardner | CB | Cincinnati | |
| Detroit (from LA Rams) | Treylon Burks | WR | Arkansas | |
| Green Bay | Christian Harris | LB | Alabama | |
| LA Chargers | Derion Kendrick | CB | Georgia | |
| Dallas | George Karlaftis | DE | Purdue | |
| Baltimore | Trevor Lindenbaum | C | Iowa | |
| Arizona | Chris Olave | WR | Ohio State |
