April 28, 2021 7:31 PM
| # | Team | Player | Position | School | Class |
|---|---|---|---|---|---|
| Jacksonville | Trevor Lawrence | QB | Clemson | JR | |
| NY Jets | Zach Wilson | QB | Brigham Young | JR | |
| San Francisco (from Houston thru Miami) | Mac Jones | QB | Alabama | JR | |
| Atlanta | Kyle Pitts | TE | Florida | JR | |
| Cincinnati | Ja'Marr Chase | WR | LSU | JR | |
| Miami (from Philadelphia) | Jaylen Waddle | WR | Alabama | JR | |
| Detroit | DeVonta Smith | WR | Alabama | SR | |
| Carolina | Penei Sewell | OT | Oregon | JR | |
| Denver | Trey Lance | QB | North Dakota State | RSO | |
| Dallas | Patrick Surtain | CB | Alabama | JR | |
| NY Giants | Micah Parsons | OLB | Penn State | JR | |
| Philadelphia (from San Francisco thru Miami) | Jaycee Horn | CB | South Carolina | JR | |
| LA Chargers | Rashawn Slater | OT | Northwestern | SR | |
| Minnesota | Alijah Vera-Tucker | OG | Southern California | JR | |
| New England | Justin Fields | QB | Ohio State | JR | |
| Arizona | Caleb Farley | CB | Virginia Tech | JR | |
| Las Vegas | Jeremiah Owusu-Koramoah | OLB | Notre Dame | JR | |
| Miami | Azeez Ojulari | OLB | Georgia | RSO | |
| Washington | Christian Darrisaw | OT | Virginia Tech | JR | |
| Chicago | Teven Jenkins | OT | Oklahoma State | SR | |
| Indianapolis | Kwity Paye | DE | Michigan | SR | |
| Tennessee | Elijah Moore | WR | Mississippi | JR | |
| NY Jets (from Seattle) | Greg Newsome | CB | Northwestern | JR | |
| Pittsburgh | Najee Harris | RB | Alabama | SR | |
| Jacksonville (from LA Rams) | Trevon Moehrig | S | Texas Christian | JR | |
| Cleveland | Jamin Davis | ILB | Kentucky | JR | |
| Baltimore | Rashod Bateman | WR | Minnesota | JR | |
| New Orleans | Jaelan Phillips | DE | Miami | JR | |
| Green Bay | Landon Dickerson | C | Alabama | SR | |
| Buffalo | Gregory Rousseau | DE | Miami | RSO | |
| Baltimore (from Kansas City) | Jayson Oweh | OLB | Penn State | RSO | |
| Tampa Bay | Christian Barmore | DT | Alabama | RSO |
