April 27, 2022 9:18 PM
| # | Team | Player | Position | Class | College |
|---|---|---|---|---|---|
| Jacksonville | Travon Walker | DE | JR | Georgia | |
| Detroit | Aidan Hutchinson | DE | SR | Michigan | |
| Houston | Ikem Ekwonu | OT | JR | North Carolina State | |
| NY Jets | Kayvon Thibodeaux | DE | JR | Oregon | |
| NY Giants | Charles Cross | OT | RSO | Mississippi State | |
| Carolina | Kenny Pickett | QB | SR+ | Pittsburgh | |
| NY Giants (from Chicago) | Ahmad Gardner | CB | JR | Cincinnati | |
| Atlanta | Malik Willis | QB | SR | Liberty | |
| Seattle (from Denver) | Evan Neal | OT | JR | Alabama | |
| NY Jets (from Seattle) | Garrett Wilson | WR | JR | Ohio State | |
| Washington | Jameson Williams | WR | JR | Alabama | |
| Minnesota | Derek Stingley | CB | JR | LSU | |
| Houston (from Cleveland) | Kyle Hamilton | S | JR | Notre Dame | |
| Baltimore | Jermaine Johnson | OLB | SR+ | Florida State | |
| Philadelphia (from Miami) | Jordan Davis | DT | SR | Georgia | |
| New Orleans (from Indianapolis thru Philadelphia) | Trevor Penning | OT | SR | Northern Iowa | |
| LA Chargers | Kenyon Green | OG | JR | Texas A&M | |
| Philadelphia (from New Orleans) | Drake London | WR | JR | Southern California | |
| New Orleans (from Philadelphia) | Chris Olave | WR | SR | Ohio State | |
| Pittsburgh | Desmond Ridder | QB | SR | Cincinnati | |
| New England | Trent McDuffie | CB | JR | Washington | |
| Green Bay (from Las Vegas) | George Karlaftis | DE | JR | Purdue | |
| Arizona | Treylon Burks | WR | JR | Arkansas | |
| Dallas | Zion Johnson | OG | SR+ | Boston College | |
| Buffalo | Breece Hall | RB | JR | Iowa State | |
| Tennessee | Devin Lloyd | ILB | SR | Utah | |
| Tampa Bay | Devonte Wyatt | DT | SR+ | Georgia | |
| Green Bay | Tyler Smith | OT | RSO | Tulsa | |
| Kansas City (from San Francisco thru Miami) | Jahan Dotson | WR | SR | Penn State | |
| Kansas City | Boye Mafe | OLB | SR | Minnesota | |
| Cincinnati | Tyler Linderbaum | C | JR | Iowa | |
| Detroit (from LA Rams) | Daxton Hill | S | JR | Michigan |
