December 30, 2021 9:32 AM
| # | Team | Player | POS | College |
|---|---|---|---|---|
| Jacksonville | Kayvon Thibodeaux | DE | Oregon | |
| Detroit | Aidan Hutchinson | DE | Michigan | |
| Houston | Derek Stingley | CB | LSU | |
| NY Jets | Kyle Hamilton | SS | Notre Dame | |
| NY Giants | Evan Neal | OT | Alabama | |
| NY Jets (from Seattle) | Treylon Burks | WR | Arkansas | |
| Carolina | Ikem Ekwonu | G/T | North Carolina State | |
| NY Giants (from Chicago) | Jameson Williams | WR | Alabama | |
| Washington | Kenny Pickett | QB | Pittsburgh | |
| Atlanta | Jermaine Johnson | DE | Florida State | |
| Denver | Matt Corral | QB | Mississippi | |
| Minnesota | George Karlaftis | DE | Purdue | |
| New Orleans | Charles Cross | OT | Mississippi State | |
| Cleveland | DeMarvin Leal | DT | Texas A&M | |
| Pittsburgh | Tyler Linderbaum | C | Iowa | |
| Philadelphia (from Miami) | Nakobe Dean | LB | Georgia | |
| LA Chargers | Devin Lloyd | LB | Utah | |
| Baltimore | Drake London | WR | Southern California | |
| Philadelphia | David Ojabo | DE | Michigan | |
| Miami (from San Francisco) | Isaiah Spiller | RB | Texas A&M | |
| Las Vegas | Jordan Davis | DT | Georgia | |
| Cincinnati | Ahmad Gardner | CB | Cincinnati | |
| Buffalo | Garrett Wilson | WR | Ohio State | |
| New England | Kaiir Elam | CB | Florida | |
| Philadelphia (from Indianapolis) | Desmond Ridder | QB | Cincinnati | |
| Tennessee | Kenyon Green | G/T | Texas A&M | |
| Arizona | Roger McCreary | CB | Auburn | |
| Tampa Bay | Darian Kinnard | G/T | Kentucky | |
| Detroit (from LA Rams) | Malik Willis | QB | Liberty | |
| Dallas | Andrew Booth | CB | Clemson | |
| Kansas City | Trent McDuffie | CB | Washington | |
| Green Bay | Jahan Dotson | WR | Penn State |
