First round
| # | Team | Player | POS | School |
|---|---|---|---|---|
| Cincinnati | Joe Burrow | QB | LSU | |
| Washington | Chase Young | DE | Ohio State | |
| Detroit | Jeff Okudah | CB | Ohio State | |
| NY Giants | Isaiah Simmons | LB | Clemson | |
| Miami | Justin Herbert | QB | Oregon | |
| LA Chargers | Tua Tagolavoa | QB | Alabama | |
| Carolina | Derrick Brown | DT | Auburn | |
| Arizona | CeeDee Lamb | WR | Oklahoma | |
| Jacksonville | Javon Kinlaw | DT | South Carolina | |
| Cleveland | Tristan Wirfs | OT | Iowa | |
| NY Jets | Jerry Jeudy | WR | Alabama | |
| Las Vegas | Henry Ruggs | WR | Alabama | |
| San Francisco (from Indianapolis) | Justin Jefferson | WR | LSU | |
| Tampa Bay | Jedrick Wills | OT | Alabama | |
| Denver | Mekhi Becton | OT | Louisville | |
| Atlanta | CJ Henderson | CB | Florida | |
| Dallas | K'Lavon Chaisson | ER | LSU | |
| Miami (from Pittsburgh) | Andrew Thomas | OB | Georgia | |
| Las Vegas (from Chicago) | Austin Jackson | OT | Southern California | |
| Jacksonville (from LA Rams) | Josh Jones | OT | Houston | |
| Philadelphia | Kenneth Murray | LB | Oklahoma | |
| Minnesota (from Buffalo) | Grant Delpit | FS | LSU | |
| New England | Jordan Love | QB | Utah State | |
| New Orleans | Patrick Queen | LB | LSU | |
| Minnesota | Tee Higgins | WR | Clemson | |
| Miami (from Houston) | D'Andre Swift | RB | Georgia | |
| Seattle | Yetur Gross-Matos | DE | Penn State | |
| Baltimore | Denzel Mims | WR | Baylor | |
| Tennessee | Ezra Cleveland | OT | Boise State | |
| Green Bay | Laviska Shenault | WR | Colorado | |
| San Francisco | Xavier McKinney | FS | Alabama | |
| Kansas City | Jaylon Johnson | CB | Utah |
Second round
| 33 | Cincinnati | Zack Baun | LB | Wisconsin |
| 34 | Indianapolis (from Washington) | Brandon Aiyuk | WR | Arizona State |
| 35 | Detroit | Ross Blacklock | DT | TCU |
| 36 | NY Giants | Cesar Ruiz | C | Michigan |
| 37 | LA Chargers | AJ Epenesa | DE | Iowa |
| 38 | Carolina | Kristian Fulton | CB | LSU |
| 39 | Miami | Jalen Reagor | WR | TCU |
| 40 | Houston (from Arizona) | Michael Pittman | WR | Southern California |
| 41 | Cleveland | Jeremy Chinn | SS | Southern Illinois |
| 42 | Jacksonville | Trevon Diggs | CB | Alabama |
| 43 | Chicago (from Las Vegas) | Jeff Gladney | CB | TCU |
| 44 | Indianapolis | Cole Kmet | TE | Notre Dame |
| 45 | Tampa Bay | Jonathan Taylor | RB | Wisconsin |
| 46 | Denver | Chase Claypool | WR | Notre Dame |
| 47 | Atlanta | Antoine Winfield | FS | Minnesota |
| 48 | NY Jets | Isaiah Wilson | OT | Georgia |
| 49 | Pittsburgh | Terrell Lewis | ER | Alabama |
| 50 | Chicago | Jacob Eason | QB | Washington |
| 51 | Dallas | Lloyd Cushenberry | C | Clemson |
| 52 | LA Rams | JK Dobbins | RB | Ohio State |
| 53 | Philadelphia | KJ Hamler | WR | Penn State |
| 54 | Buffalo | Jonathan Greenard | DE | Florida |
| 55 | Baltimore (from New England thru Atlanta) | AJ Terrell | CB | Clemson |
| 56 | Miami (from New Orleans) | Ashtyn Davis | FS | California |
| 57 | Minnesota | Noah Igbinoghene | CB | Auburn |
| 58 | Houston | Justin Madubuike | DT | Texas A&M |
| 59 | Seattle | Clyde Edwards-Helaire | RB | LSU |
| 60 | Baltimore | Logan Wilson | LB | Wyoming |
| 61 | Tennessee | Josh Uche | ER | Michigan |
| 62 | Green Bay | Adam Trautman | TE | Dayton |
| 63 | Seattle (from San Francisco thru KC) | Neville Gallimore | DT | Oklahoma |
| 64 | Kansas City | Robert Hunt | OG | Louisiana |
Third round
| 65 | Cincinnati | Lucas Niang | OT | TCU |
| 66 | Washington | Harrison Bryant | TE | Florida Atlantic |
| 67 | Detroit | Brad Anae | DE | Utah |
| 68 | NY Jets (from NY Giants) | Marlon Davidson | DE | Auburn |
| 69 | Carolina | Kyle Dugger | SS | Lenoir-Rhyne |
| 70 | Miami | James Lynch | DE | Baylor |
| 71 | LA Chargers | Prince Tega Wanogho | OT | Auburn |
| 72 | Arizona | Curtis Weaver | DE | Boise State |
| 73 | Jacksonville | Jake Fromm | QB | Georgia |
| 74 | Cleveland | Malik Harrison | LB | Ohio State |
| 75 | Indianapolis | Cameron Dantzler | CB | Mississippi State |
| 76 | Tampa Bay | Alton Robinson | DE | Syracuse |
| 77 | Denver | Damon Arnette | CB | Ohio State |
| 78 | Atlanta | Julian Okwara | DE | Notre Dame |
| 79 | NY Jets | AJ Dillon | RB | Boston College |
| 80 | Las Vegas | Bryce Hall | CB | Virginia |
| 81 | Las Vegas (from Chicago) | Jalen Hurts | QB | Oklahoma |
| 82 | Dallas | Troy Pride | CB | Notre Dame |
| 83 | Denver (from Pittsburgh) | Jordyn Brooks | LB | Texas Tech |
| 84 | LA Rams | Matt Peart | OT | UConn |
| 85 | Detroit (from Philadelphia) | Cam Akers | RB | Florida State |
| 86 | Buffalo | Amik Robertson | CB | Louisiana Tech |
| 87 | New England | Albert Okwuegbunam | TE | Missouri |
| 88 | New Orleans | John Simpson | OG | Clemson |
| 89 | Minnesota | Damien Lewis | OG | LSU |
| 90 | Las Vegas (from Houston) | Raekwon Davis | DT | Alabama |
| 91 | Cleveland (from Seattle thru Houston) | Gabriel Davis | WR | Central Florida |
| 92 | Baltimore | Matt Hennessey | C | Temple |
| 93 | Tennessee | Bryan Edwards | WR | South Carolina |
| 94 | Green Bay | Tyler Biadasz | C | Wisconsin |
| 95 | Denver (from San Francisco) | Nick Harris | C | Washington |
| 96 | Kansas City | Zack Moss | RB | Utah |
| 97c | Houston | Jabari Zuniga | ER | Florida |
| 98c | New England | DaVon Hamilton | DT | Ohio State |
| 99c | NY Giants | Darrell Taylor | DE | Tennessee |
| 100c | New England | Jacob Phillips | LB | LSU |
| 101c | Seattle | Ben Bartch | G/T | Saint Johns |
| 102c | Pittsburgh | Saadiq Charles | OT | LSU |
| 103c | Philadelphia | Darney Holmes | CB | UCLA |
| 104c | LA Rams | Khalid Kareem | ER | Notre Dame |
| 105c | Minnesota | Jason Strowbridge | DE | North Carolina |
| 106c | Baltimore | Antonio Gibson | RB/WR | Memphis |
