April 10, 2022 11:42 AM
| # | Team | Player | POS | College |
|---|---|---|---|---|
| Jacksonville | Aidan Hutchinson | DE | Michigan | |
| Detroit | Kayvon Thibodeaux | DE | Oregon | |
| Houston | Travon Walker | DE | Georgia | |
| NY Jets | Sauce Gardner | CB | Cincinnati | |
| NY Giants | Ickey Ekwonu | OT | North Carolina State | |
| Carolina | Malik Willis | QB | Liberty | |
| NY Giants (from Chicago) | Jermaine Johnson | OLB | Florida State | |
| Atlanta | Kenny Pickett | QB | Pittsburgh | |
| Seattle (from Denver) | Evan Neal | OT | Alabama | |
| NY Jets (from Seattle) | Drake London | WR | Southern California | |
| Washington | Garrett Wilson | WR | Ohio State | |
| Minnesota | Derek Stingley | CB | LSU | |
| Houston (from Cleveland) | Kyle Hamilton | S | Notre Dame | |
| Baltimore | Trent McDuffie | CB | Washington | |
| Philadelphia (from Miami) | Devin Lloyd | LB | Utah | |
| New Orleans (from Indianapolis thru Philadelphia | Charles Cross | OT | Mississippi State | |
| LA Chargers | Trevor Penning | OT | Northern Iowa | |
| Philadelphia (from New Orleans) | Treylon Burks | WR | Arkansas | |
| NY Orleans (from Philadelphia) | Desmond Ridder | QB | Cincinnati | |
| Pittsburgh | Matt Corral | QB | Mississippi | |
| New England | Jordan Davis | DT | Georgia | |
| Green Bay (from Las Vegas) | Jameson Williams | WR | Alabama | |
| Arizona | George Karlaftis | DE | Purdue | |
| Dallas | Devonte Wyatt | DT | Georgia | |
| Buffalo | Breece Hall | RB | Iowa State | |
| Tennessee | Nakobe Dean | LB | Georgia | |
| Tampa Bay | Kenyon Green | G/T | Texas A&M | |
| Green Bay | Chris Olave | WR | Ohio State | |
| Kansas City (from San Francisco thru Miami) | Jahan Dotson | WR | Penn State | |
| Kansas City | Arnold Ebiketie | OLB | Penn State | |
| Cincinnati | Tyler Linderbaum | C | Iowa | |
| Detroit (from LA Rams) | Sam Howell | QB | North Carolina |
Second round
| 33 | Jacksonville | Christian Watson | WR | North Dakota State |
| 34 | Detroit | Andrew Booth | CB | Clemson |
| 35 | NY Jets | Bernhard Raimann | OT | Central Michigan |
| 36 | NY Giants | Kaiir Elam | CB | Florida |
| 37 | Houston | Zion Johnson | C/G | Boston College |
| 38 | NY Jets (from Carolina) | Kenny Walker | RB | Michigan State |
| 39 | Chicago | Skyy Moore | WR | Western Michigan |
| 40 | Seattle (from Denver) | Tyler Smith | OT | Tulsa |
| 41 | Seattle | David Ojabo | DE | Michigan |
| 42 | Indianapolis (from Washington) | Abraham Lucas | OT | Washington State |
| 43 | Atlanta | George Pickens | WR | Georgia |
| 44 | Cleveland | Perrion Winfrey | DT | Oklahoma |
| 45 | Baltimore | Boye Mafe | ER | Minnesota |
| 46 | Minnesota | Sam Williams | DE | Mississippi |
| 47 | Washington (from Indianapolis) | Kyler Gordon | CB | Washington |
| 48 | Chicago (from LA Chargers) | Nicholas Petit-Frere | OT | Ohio State |
| 49 | New Orleans | Roger McCreary | CB | Auburn |
| 50 | Kansas City (from Miami) | Travis Jones | DT | UConn |
| 51 | Philadelphia | Dax Hill | S | Michigan |
| 52 | Pittsburgh | Alontae Taylor | CB | Tennessee |
| 53 | Green Bay (from Las Vegas) | Logan Hall | DE | Houston |
| 54 | New England | Tariq Woolen | CB | Texas-San Antonio |
| 55 | Arizona | Lewis Cine | FS | Georgia |
| 56 | Dallas | Quay Walker | LB | Georgia |
| 57 | Buffalo | Zyon McCollum | CB | Sam Houston State |
| 58 | Atlanta (from Tennessee) | Drake Jackson | ER | Southern California |
| 59 | Green Bay | Trey McBride | TE | Colorado State |
| 60 | Tampa Bay | Cameron Thomas | DE | San Diego State |
| 61 | San Francisco | Jamaree Salyer | OG | Georgia |
| 62 | Kansas City | Leo Chenal | LB | Wisconsin |
| 63 | Cincinnati | Myjai Sanders | OLB | Cincinnati |
| 64 | Denver (from LA Rams) | Christian Harris | LB | Alabama |
Third round
| 65 | Jacksonville | Dylan Parham | C/G | Memphis |
| 66 | Detroit | Phil Mathis | DT | Alabama |
| 67 | NY Giants | James Cook | RB | Georgia |
| 68 | Houston | John Metchie | WR | Alabama |
| 69 | NY Jets | Amare' Barno | OLB | Virginia Tech |
| 70 | Jacksonville (from Carolina) | Isaiah Spiller | RB | Texas A&M |
| 71 | Chicago | Daniel Faalele | OT | Minnesota |
| 72 | Seattle | Chad Muma | LB | Wyoming |
| 73 | Indianapolis (from Washington) | Alec Pierce | WR | Cincinnati |
| 74 | Atlanta | Jaquan Brisker | S | Penn State |
| 75 | Denver | Jalyn Armour-Davis | CB | Alabama |
| 76 | Baltimore | Pierre Strong | RB | South Dakota State |
| 77 | Minnesota | Cole Strange | OG | Chattanooga |
| 78 | Cleveland | Brandon Smith | OLB | Penn State |
| 79 | LA Chargers | Calvin Austin | WR | Memphis |
| 80 | Houston (from New Orleans) | Carson Strong | QB | Nevada |
| 81 | NY Giants (from Miami) | Greg Dulcich | TE | UCLA |
| 82 | Atlanta (from Indianapolis) | Cam Jurgens | C/G | Nebraska |
| 83 | Philadelphia | Josh Paschal | DE | Kentucky |
| 84 | Pittsburgh | Kellen Diesch | OT | Arizona State |
| 85 | New England | Wan'Dale Robinson | WR | Kentucky |
| 86 | Las Vegas | Sean Rhyan | G/T | UCLA |
| 87 | Arizona | Jalen Tolbert | WR | South Alabama |
| 88 | Dallas | Luke Goedeke | G/T | Central Michigan |
| 89 | Buffalo | Darian Kinnard | G/T | Kentucky |
| 90 | Tennessee | Velus Jones | WR | Tennessee |
| 91 | Tampa Bay | Jelani Woods | TE | Virginia |
| 92 | Green Bay | DeMarvin Leal | DE | Texas A&M |
| 93 | San Francisco | Coby Bryant | CB | Cincinnati |
| 94 | Kansas City | Jalen Pitre | S | Baylor |
| 95 | Cincinnati | Josh Jobe | CB | Alabama |
| 96 | Denver (from LA Rams) | Channing Tindall | LB | Georgia |
| 97c | Detroit | Nick Cross | S | Maryland |
| 98c | New Orleans | David Bell | WR | Purdue |
| 99c | Cleveland | Kingsley Enagbare | DE | South Carolina |
| 100c | Baltimore | Dameon Pierce | RB | Florida |
| 101c | Philadelphia (from New Orleans) | Kalon Barnes | CB | Baylor |
| 102c | Miami | Nik Bonitto | OLB | Oklahoma |
| 103c | Kansas City | Marcus Jones | CB | Houston |
| 104c | LA Rams | Jesse Luketa | ER | Penn State |
| 105c | San Francisco | Troy Andersen | OLB | Montana State |
